Intact omentum for ocular vascularization

the iris sphincter to a miotic drug. Different lipid solubilities and degradation of the drug by the cholinesterases present in the iris are but two examples. It was possible by the method described to evaluate the overall miotic activities of series of ACh agonists and cholinesterase inhibitors in the mouse eye. By comparing the dose-response dependence of non-ester acetylcholine-agonists (e.g., oxotremorine) to that of aminoacetates (e.g., aceclidine) it should be possible to estimate to what extent the cholinesterase activity inlluences, e.g., the required drug concentration or the duration of miotic activity. Preliminary results, to be published, were found to be in good agreement with cholinergic activity data obtained from isolated organs, e.g., isolated guinea pig ileum.